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You may need to install the remotes package first.
The first column disease specifies the supported
diseases in the package. The other three columns, which are outcome
types (fatal, non-fatal and
fatal-and-non-fatal), show the last knot (based on the
available data points) for the specific disease. We don’t have
confidence that our meta-analysis is reliable after this point, and
assumes an onward flat relationship. Whenever a disease such as
all-cause-cvd doesn’t have an outcome type
non-fatal, it will be NA. More will follow in
the next section.
| disease | fatal | non-fatal | fatal-and-non-fatal |
|---|---|---|---|
| all-cause-cancer | 19.13777 | NA | 19.49427 |
| all-cause-cvd | 21.33552 | NA | 20.11288 |
| all-cause-dementia | NA | 13.51200 | 11.41597 |
| all-cause-mortality | 12.68428 | NA | 12.68428 |
| alzheimer’s-disease | NA | 22.36750 | 13.63786 |
| bladder-cancer | NA | NA | 13.45000 |
| breast-cancer | 15.47684 | NA | 26.75480 |
| colon-cancer | NA | NA | 20.10136 |
| coronary-heart-disease | 11.00136 | NA | 17.96000 |
| depression | NA | 14.56452 | 14.56452 |
| depressive-symptoms | NA | 11.75641 | 11.75641 |
| diabetes | NA | NA | 17.53800 |
| endometrial-cancer | NA | NA | 21.16857 |
| esophageal-cancer | NA | NA | 21.82207 |
| gastric-cardia-cancer | NA | NA | 22.52300 |
| head-and-neck-cancer | NA | NA | 13.59235 |
| heart-failure | NA | NA | 24.41750 |
| kidney-cancer | NA | NA | 14.81429 |
| liver-cancer | NA | NA | 21.82154 |
| lung-cancer | 20.20636 | NA | 14.17460 |
| major-depression | NA | 16.54304 | 16.54304 |
| myeloid-leukemia | NA | NA | 10.06429 |
| myeloma | NA | NA | 21.83250 |
| parkinson’s-disease | NA | 15.11423 | 15.17000 |
| prostate-cancer | 14.87857 | NA | 27.26046 |
| rectum-cancer | NA | NA | 18.09230 |
| stroke | 11.00400 | NA | 15.01652 |
| vascular-dementia | NA | NA | 16.85333 |
Get response for dose 40 for all-cause-cvd with the default quantile 0.5 and censoring at doubling of WHO’s recommended level of physical activity for adults (17.5 MMETs hours per week).
The quantile’s value is between 0 and 1 [excluding the
boundary values]
drpa::dose_response(cause = 'all-cause-cvd', outcome_type = 'fatal-and-non-fatal', dose = 40,
quantile = 0.5, confidence_intervals = T, censor_method = 'WHO-DRL')
#> rr lb ub
#> 1 0.6736267 0.6273602 0.7233052Description of the arguments are mentioned below:
| Argument | Description |
|---|---|
| cause | All-cause-mortality or disease name |
| outcome_type | Either one of the three possibilities for outcome type: fatal, non-fatal or fatal-and-non-fatal |
| dose | Dose (all-cause or disease) |
| quantile | Numeric value between 0 and 1 - default is 0.5. This
captures the range of dose values between lower and
upper confidence levels. |
| censor_method | This determines whether any censor method applies to the
dose-response relationship. There are three possibilities:
none, 75person_years (to use 75th percentile
using person years) or WHO-DRL (WHO’s recommended physical
activity per week 8.75 when doubled, so 17.5
MMETs hours per week). The default value is WHO-DRL - a
fixed censor point at 17.5 after which the relationship
remains the same. |
| confidence_intervals | Boolean variable to determine whether confidence intervals are returned or not - default false |